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Where should I stay in Rome?
The best Rome hotels fill up quickly, so it's a good idea to book your hotel room as soon as you begin planning your Rome vacation, that way you can ensure the best room possible. Rooms in hotels closer to the center of city tend to be more expensive, with the price gradually decreasing the farther out you get. As a general rule you want to look for hotel rooms east of the Tiber River and west of Station Termini.
One huge bonus of booking a hotel room in the center of town is that you can walk to most of the Rome tours and attractions you might be interested in seeing. While there is public transportation in Rome it can often be much quicker and easier to walk to attractions if you're staying in a hotel nearby.